For example, in ion-solvatation, also relevant to proteins, in the first sphere, i.e. the inner yard of the solvatation, the energy of bonding is quite much (up to 100 cal / mole, i.e. of the same order of magnitude as in the connection in so-called chief-valence bonds). In the second sphere the energy of the [omnipresent] thermal motion is already hardly surpassed anymore. One has, referring back to older ideas, indicated the inner solvatation as "chemical" and the outer as physical solvatation.